Uses high purity and hig qality materials that is made by Hanook Korus Pharm Biotechnology Includes Noble Prize Awarded Component EGF High purity of EGF protein and adding hGH protein restores dry and irritated skin, an anti-aging ampoule that keeps skin youthful by minimizing signs age
BeautiO Revital Ampoule
Our cosmetis is based on Bio ingredients EGf and hGH.
EGF is is a single-chain polypeptide consisting of 53 amino acids with a molecularweight about 6,200 daltons and Human EGF is a potent stimulator to epithelial and endothelial cells and fibroblast proliferation both in vitro and in vivo, which results in its potential as a wound-healing agent with epidermal activity. EGF manufactured by HKP has very high purity (more than 95 %), and significantly induces cellular proliferation.
hGH known as somatropin, plays important roles in growth control, promotion of growth, development of cells, and regulation of many metabolic processes. hGH manufactured by HKP is a pharmaceutical-grade recombinant protein, which proved its safety and biological properties in vitro and in vivo.
This Ampoule's functions are improve epidermal barrier, effects that give your skin elasticity and vivacity, help whitening and wrinkle treatment and keep your skin moist and brighten your complexion.
In addition to the regenerating soothing moisturizing effect of EGF products, the effects of hGH can prevent not only biological aging but also skin diseases beyond the range of other hormones.
< In vitro test report of BeatiO effect>
In this test, intracellular collagen production and intracellular collagenase activity inhibitory ability of the test substances are measured to evaluate wrinkle improvement effect.
1. Cell viability analysis
The cell viability was not significantly decreased at the concentrations of 0.25, 0.5, 1, 2 and 4 ppm.
2. Analysis of intracellular collagen production
The product of intracellular collagen was significantly increased at 0.5, 1, 2 and 4 ppm of rhEGF, 1,2 and 4 ppm of rhGH and 0.5, 1 and 2 rhEGH + rhGH(p<0.05).
3. Inhibition of intracellular collagenase activity
The activity of intracellular collagenase was significantly decreased at 0.25, 1, 2 and 4 ppm of rhGH among the three raw materials.
On the other hand, rhEGF, rhEGF + rhGH inhibited the activity of collagenase, but there was no significant difference.
As a result of evaluation of wrinkle improving effect on the three kinds of raw materials, rhEGF, rhGH, rhEGF + rhGH significantly increased collagen production, and rhGH significantly inhibited collagenase activity.
Therefore, it is considered that the three kinds of raw materials help to improve wrinkles.
[ Fig 1. ]
Cell viability in human dermal fibroblasts. The data was expressed as % of vehicle control
( Mean ± SD, n=3, *p<0.05, rhEGF, rhGH, rhEGF + rhGH vs. Vehicle control )
Conclusions : The cell viability was not significantly decreased at the concentrations of 0.25, 0.5, 1, 2 and 4 ppm.
[ Fig 2.]
PIP contents in human dermal fibroblasts after treatment. The data are expressed as % of vehicle control
( Mean ± SD, rhEGF, rhGH, rhEGf + rhGH vs. Vehicle control )
Conclusions : The results showed that 0.5, 1, 2 and 4 ppm of rhEGF, 1, 2 and 4 ppm of rhGH and
0.5, 1, 2 and 4 ppm collagen production of rhEGF + rhGH were significantly increased ( p<0.05, Fig2. )
[ Fig 3. ]
MMP-1 contents in human fibroblasts after treatment. The data are expressed as % of vehicle control
( Mean ± SD, *p<0.05, rhEGF, rhGH, rhEGF + rhGH vs. Vehicle control.
Conclusions : The activity of intracellular collagenase was significantly decreased at 0.25, 1, 2 and 4 ppm of rhGH
among the three raw materials.
On the other hand, rhEGF, rhEGF + rhGH inhibited the activity of collagenase, but there was significant difference.
Manufacture of Cosmetics(Skin Care, Hair Care, Body Care, Perfume)
- Bio - finished Plant ( 2017. 04 )
- Antibody Bio-Production Plant ( 2019. 05 ~ )
Institute in Seoul, Jaecheon, Chuncheon.
- Developing Biosimilar and Better Platform
- Researching on Chemical Medicines
We would like to express our sincere gratitude to all of our customers for their unlimited interest and trust toward HANKOOK KORUS.
We, HANKOOK KORUS, is a comprehensive pharmaceutical company that has contributed to the improvement of the national health by producing and selling about 130 quality medicines since its establishment in 1999.
We have done our very best so far fulfilling our corporate mission; “A global-wide pharmaceutical company that loves life and contributes to human society.” As fruits of assertive investment and export capacity of holding company GL Rapha, The award for the export of 1 million dollars in 2008, 5 million in 2009, and 10 million in 2010 account for the rapid growth of our exports.
We, HANKOOK KORUS, have completed the Chuncheon-BIO-plant in 2011 with the aim of becoming a global pharmaceutical/biotech company, and are meeting the rapidly growing global market. In line with the growing cosmeceutical trend with K-beauty, we are trying to advance into the global market by making BeautiO, a cosmetic product that is based on BIO API such as EGF and hGH, and health functional products that contribute to the health of people all over the world.
Bio Product will be a new strategy for the future of HANKOOK KORUS Pharmaceuticals, and it will be a stepping stone to grow into a Global Bio Company.
Jae Kan Whang
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